Toxicokinetics of Deoxynivalenol in Dezhou Male Donkeys after Oral Administration

Deoxynivalenol (DON) is detected in different types of foods and feeds, inducing toxicity humans animals. After entering the organism, DON first appears plasma; then, it rapidly absorbed distributed various organs tends to accumulate body exert its toxic effects. This study was performed investigate toxicokinetics on Dezhou male donkeys after a single oral dose 500 μg/kg·BW (body weight). The plasma collected at 0, 5, 10, 15, 20, 30, 45 min, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 6, 9, 12, 24, 48, 72, 96 120 h administration, feces urine were 0 6 intervals up 24 h, followed by 4 h. concentrations plasma, determined HPLC. peak concentration 174.30 μg/L, which occurred 1.07 gavage. recovery unchanged amounted 19.98% 6.74%, respectively. Overall, slowly eliminated within following dose, can lead accumulation if ingested for long time.